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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1016/0025-5416(79)90020-x

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ISSN

1573-8221

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Analysis of Mechanisms of Interaction between Cipr

Authors: S I Sazonova M R Karpova Yu N Il’yushenkova N V Varlamova Yu B Lishmanov
Publish Date: 2014/10/24
Volume: 157, Issue: 6, Pages: 732-734
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Abstract

Mechanisms of interaction between ciprofloxacinbased radiopharmaceutical labeled with technetium99m and cultured Staphylococcus aureus were studied The substance reagent for radiopharmaceutical and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures which confi rmed specifi c antibacterial activity of technetium99mlabeled ciprofloxacin The technetium99mlabeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture which indicates the existence of an additional nonspecific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus Our experiment ruled out the possibility of binding free technetium99m at concentrations 5 its concentration in the radiopharmaceutical with Staphylococcus aureus

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