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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/s40620-014-0087-7

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ISSN

1573-8221

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Effect of histochrome on the severity of delayed e

Authors: B Ya Ryzhavsky O A Lebedko D S Belolubskaya
Publish Date: 2008/12/06
Volume: 146, Issue: 2, Pages: 267-
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Abstract

The effects of histochrome on the severity of delayed effects of prenatal exposure to lead nitrate were studied in the rat brain Exposure of pregnant rats to lead nitrate during activation of free radical oxidation reduced activity of NADHand NADPHdehydrogenases in cortical neurons of their 40dayold progeny reduced the number of neurons in a visual field increased the number of pathologically modified neurons and stimulated rat motor activity in an elevated plusmaze Two intraperitoneal injections of histochrome in a dose of 01 mg/kg before and after lead citrate challenge attenuated the manifestations of oxidative stress and prevented the changes in some morphological and histochemical parameters of the brain developing under the effect of lead exposure

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