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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1016/0017-9310(73)90173-7

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ISSN

1573-8221

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Processes of Homeostatic Proliferation in the Path

Authors: E V Goiman O T Kudaeva N A Ilyina V I Borisov V S Kozhevnikov O P Kolesnikova V A Kozlov
Publish Date: 2010/06/16
Volume: 149, Issue: 1, Pages: 54-56
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Abstract

Lymphopenia developing at the early stage of chronic graftversushost reaction is associated with increased content of IL7 in the peripheral blood and leads to an increase of the CD4+ and CD8+ cell subpopulations in the spleen of the recipient After 3 months some animals develop autoimmune glomerulonephritis lupus recipients High levels of IL7 and Tcells with the memory cell phenotype CD4+CD45RBlow and CD8+CD45RBlow persist in these animals in contrast to nonlupus recipients without signs of autoimmune disease This can attest to the involvement of homeostatic proliferation processes in the formation of autoimmune disease in this model

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