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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1002/ange.19710831502

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ISSN

1573-8221

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Molecular Factors of CytokineDependent Activation

Authors: I E Esimova O I Urazova M S Ignatova V V Novitskii Yu V Kolobovnikova
Publish Date: 2015/07/25
Volume: 159, Issue: 3, Pages: 390-392
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Abstract

The parameters characterizing antituberculous immune response at the stage of cytokinedependent activation of T cells were analyzed in 90 patients with pulmonary tuberculosis before etiotropic therapy Immunophenotyping of T cells for IL12Rβ2 WSX1 and gp130 surface markers and Tbet intracellular transcription factor was carried out after specific IL12/IL27 induction of cells in vitro An increase in the counts of CD3+Tbet+ CD3+IL12Rβ2 + and CD3+WSX1+gp130+ cells and the level of T cells with high expression of WSX1 inhibitory molecule CD3+WSX1hi+gp130− and CD3+WSX1hi+gp130+ was detected The type of disorders in the inductive stage of antituberculous immune response did not depend on the clinical form of disease

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