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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/bf02346653

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ISSN

1573-8221

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CaSuperscript2+/Superscript Ions Regulate Acti

Authors: V A Yurkiv V I Melikhov V S Shubin
Publish Date: 2015/01/10
Volume: 158, Issue: 3, Pages: 326-328
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Abstract

We studied the effects of bivalent metal ions on activity of Na+Cl–HCO3 –ATPase was studied In contrast to Ba2+ Co2+ Zn2+ and Mn2+ ions Ca2+ and Mg2+ ions in a concentration of 025 mM completely inhibited this enzyme Histamine in vivo significantly decreased the inhibiting effect of Ca2+ on Na+Cl–HCO3 –ATPase A possible mechanism of regulation of enzyme activity by Ca2+ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl– ions was proposed

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