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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/978-3-662-49442-4

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1573-8221

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Antiarrhythmic Activity of Taurepar during Ischemi

Authors: I B Krylova V V Bul’on E N Selina N S Sapronov P D Shabanov
Publish Date: 2015/12/07
Volume: 160, Issue: 2, Pages: 228-230
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Abstract

The antiarrhythmic effect of taurepar an Nphenylalkyl derivative of taurine was examined in experiments on rats subjected to acute myocardial ischemia/reperfusion leading to arrhythmia development During acute ischemia taurepar 25 mg/kg completely prevented early postocclusion arrhythmias including extrasystoles ventricular tachycardia and ventricular fibrillation During postischemic reperfusion taurepar 25 mg/kg did not prevent extrasystoles and ventricular tachycardia but precluded the development of ventricular fibrillation and the death of animals The antiarrhythmic potency of taurepar surpassed that of lidocaine during acute myocardial ischemia and that of propranolol during ischemia/reperfusion injury The results suggest that taurepar is a promising antiarrhythmic drug with high antifibrillation activity

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