Authors: N V Ryazanceva V V Novickiy O B Zhukova A K Biktasova O E Chechina E V Sazonova M V Belkina N Yu Chasovskih Z K Khaitova
Publish Date: 2010/07/17
Volume: 149, Issue: 2, Pages: 180-183
Abstract
We studied the in vitro apoptosisinducing effect of recombinant TNFα rTNFα on blood lymphocytes from healthy donors rTNFαinduced apoptosis was accompanied by an increase in the number of cells with low mitochondrial transmembrane potential increased intracellular content of reactive oxygen species reduced content of Bcl2 BclxL and Bax proteins and elevated Bad content The molecular mechanisms of these changes are discussed
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