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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/s11517-009-0514-4

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ISSN

1573-8221

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Experiments on Alcocytes Containing Enzyme Nanopar

Authors: Yu G Kaminsky E A Kosenko Yu G Alexandrovich F I Ataullakhanov
Publish Date: 2012/06/20
Volume: 153, Issue: 1, Pages: 170-172
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Abstract

We developed a method of introduction of alcohol dehydrogenase and aldehyde dehydrogenase into mouse and human erythrocytes The possibility of using erythrocytes loaded with the two enzymes alcocytes for reducing ethanol concentration in animal blood was studied Injection of alcocytes to mice led to accelerated decrease in ethanol concentration as soon as after 5 min and this capacity of alcocytes persisted for at least 2 h Alcocytes prepared from fresh or preserved human blood did not survive in mice Thus autologous alcocytes is functionally active and can be used as a protective system in acute alcohol intoxication The developed method can be regarded as a new medical biotechnology

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