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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/s11016-015-9987-y

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ISSN

1573-8221

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Inhibition of Mitochondrial VoltageDependent Anio

Authors: Y V Saenko A V Mastilenko E S Glushchenko A V Antonova V P Svekolkin
Publish Date: 2016/06/06
Volume: 161, Issue: 1, Pages: 104-107
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Abstract

We studied the effect of inhibition of mitochondrial voltagedependent anion channels with DIDS on radiosensitivity and mitochondrial status of K562 leukemic cells The number of apoptotic and necrotic cells mitochondrial transmembrane potential and mitochondrial mass were evaluated after irradiation of cells in doses of 4 and 12 Gy in the presence and absence of the inhibitor Inhibition of mitochondrial voltagedependent anion channels increased radiosensitivity of K562 cells by 5070 and decreased both mitochondrial transmembrane potential and mitochondrial mass Inhibitors of voltagedependent anion channels are promising agents capable of improving the effectiveness of cancer radiotherapy

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