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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/bf02962256

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ISSN

1573-8221

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Effects of Antenatal Hypoxia on Tissue Homeostasis

Authors: S I Zubenko Lyu Yan M O Zhul’kov O A Lebed’ko E N Sazonova
Publish Date: 2014/07/29
Volume: 157, Issue: 3, Pages: 320-323
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Abstract

Body weight absolute and relative heart weight DNAsynthetic activity of cardiomyocytes and number of nucleoli in cardiomyocyte nuclei were reduced in newborn albino rats exposed to antennal hypoxia All these changes developed against the background of oxidative stress In mature animals the absolute and relative heart weights were decreased but the ratio of mononuclear cardiomyocytes in both ventricles was higher than in the control These changes were accompanied by an increase in the percent of collagen fi bers in the myocardial stroma In the right ventricle an increase in the cardiomyocyte length to width ratio and a decrease in the number of nucleoli were found The observed changes can probably induce heart function disturbances under pathological conditions

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