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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/bf00230117

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ISSN

1573-8221

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Effect of Polypeptides on Cell Proliferation and A

Authors: AP Ryzhak N I Chalisova N S Lin’kova T E Nichik AV Dudkov N V Kolchina G A Ryzhak R I Khalimov
Publish Date: 2017/02/27
Volume: 162, Issue: 4, Pages: 534-538
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Abstract

Polypeptide complexes derived from the bronchi blood vessels muscles kidneys ovaries testes and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals A correlation between the intensity of regeneration and animal’ age was revealed The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki67 These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing

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