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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Publisher

Springer US

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DOI

10.1002/jcd.20283

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ISSN

1573-8221

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Structural and Functional Characteristics for the

Authors: N K Zenkov E B Menshchikova N V Kandalintseva A E Prosenko
Publish Date: 2009/09/17
Volume: 147, Issue: 5, Pages: 592-
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Abstract

Structurally related phenols containing the palkylthiosulfonate substituent and partially hindered by tertbutyl groups were synthesized for the search and development of new synthetic antioxidant which would be effective in vivo in preventing free radicalinduced pathological processes Sodium 33tertbutyl4hydroxyphenylpropylthiosulfonate had high antiinflammatory activity and produced a dosedependent effect IC50=36 mg/kg Changes in the length of the carbohydrate chain in the palkyl substituent had no effect on in vitro antiradical activity of the test compounds However the decrease in the length of this chain by one methylene unit was accompanied by reduction of antiinflammatory activity of the end product Lengthening of the chain did not modulate these properties

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