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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/s00395-012-0313-1

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ISSN

1573-8221

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Effect of Thyroxin on Behavior of Mice with Inheri

Authors: E A Zubkov A V Kulikov
Publish Date: 2009/06/17
Volume: 147, Issue: 2, Pages: 217-
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Abstract

We studied effects of chronic thyroxin administration 2 mg/l for 60 days on motor activity anxiety and depressionlike behavior in cataleptic ASC/Icg and noncataleptic AKR/J strains of mice No effects of thyroxin on anxiety indicators in “open field” and “light/dark” tests were revealed in mice of the strains under study At the same time thyroxin increased moveability in the “open field” test in AKR/J mice and produced an antidepressant effect in the “forced swimming” test in animals from ASC/Icg strain Obtained results are indicative of the role of inherited predisposition to catalepsy in determining the sensitivity to thyroid hormones

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