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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer Berlin Heidelberg

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DOI

10.1016/0168-8510(90)90399-X

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1432-0428

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Presence of sulphatide 3′sulphogalactosylceramid

Authors: K Buschard T Horn K Aaen K Josefsen H Persson P Fredman
Publish Date: 1996/06/01
Volume: 39, Issue: 6, Pages: 658-666
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Abstract

The aim of the study was to investigate the distribution in the eye of sulphatide an acid glycolipid which has previously been demonstrated in islets of Langerhans nervous tissue and in kidney glomeruli of diabetic patients and against which antibodies have been found in patients with newly diagnosed insulindependent diabetes mellitus A specific monoclonal antibody Sulph I was used for detection of sulphatide by thinlayer chromatography and light and electron microscope immunohistochemistry A distinct patchy staining was found in the choroid layer and the ciliary processes The antigen was confirmed to be sulphatide and its concentration in human eyes was 30 nmol sulphatide/g wet tissue By electron microscopy antisulphatide choroid labelling was demonstrated in pericytes and in smooth muscle cells surrounding vessels No Sulph Inegative pericytes were seen Double labelling with Sulph I and antismooth muscle actin revealed that only pericytes in the eye contained sulphatide and not those in heart lung liver adrenal spleen lymph node thymus or pancreatic tissue Thus sharing of the autoantigen sulphatide has been demonstrated between islets of Langerhans and pericytes in the choroid layer of the eye

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  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
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