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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1007/bf00504715

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1432-0428

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Adenovirusmediated overexpression of Emphasis Ty

Authors: M Y Kim S H Jo J M Park T H Kim S S Im Y H Ahn
Publish Date: 2012/12/27
Volume: 56, Issue: 3, Pages: 635-643
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Abstract

Transcription factor E3 TFE3 has been shown to increase insulin sensitivity by activating insulinsignalling pathways However the role of TFE3 in glucose homeostasis is not fully understood Here we explored the possible therapeutic potential of TFE3 for the control of hyperglycaemia using a streptozotocininduced mouse model of diabetesWe achieved overabundance of TFE3 in streptozotocin mice by administering an adenovirus Ad or adenoassociated virus serotype 2 AAV2 We also performed an oral glucose tolerance test OGTT and insulin tolerance test ITT To explore molecular mechanisms of blood glucose control by TFE3 transcriptional studies on the regulation of genes involved in hepatic glucose metabolism were performed using quantitative realtime PCR and chromatin immunoprecipitation assay The binding site of TFE3 in the liver Gck gene promoter was identified using deletion and sitespecific mutation studiesOverabundance of TFE3 resulted in reduced hyperglycaemia as shown by the OGTT and ITT in streptozotocintreated mice We observed that TFE3 can upregulate Gck in a state of insulin deficiency However glucose6phosphatase and cytosolic phosphoenolpyruvate carboxykinase mRNA levels were decreased by Admediated overexpression of Tcfe3 Biochemical studies revealed that the antihyperglycaemic effect of TFE3 is due to the upregulation of Gck In primary cultured hepatocytes TFE3 increased expression of Gck mRNA Conversely small interfering RNAmediated knockdown of TFE3 resulted in a decrease in Gck mRNA

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  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
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  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
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  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
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  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
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  35. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
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  49. Harry Keen, 1925–2013
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  52. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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