Authors: K L Rasmussen C S Laugesen L Ringholm M Vestgaard P Damm E R Mathiesen
Publish Date: 2010/03/12
Volume: 53, Issue: 6, Pages: 1076-1083
Abstract
Fundus photography was performed at median 10 range 6–21 and 28 27–37 gestational weeks in 80 of 110 73 consecutively referred pregnant women with type 2 diabetes Diabetic retinopathy was classified in five stages Progression was defined as at least one stage of deterioration of diabetic retinopathy and/or development of macular oedema on at least one eye between the two examinations Macular oedema was defined as retinal thickening and/or hard exudates within a diameter of 1500 µm in the macula areaDiabetic retinopathy mainly mild was present in 11 14 women in early pregnancy Median duration of diabetes was 3 years range 0–16 years At baseline HbA1c was 64 10 mean SD systolic BP 121 13 and diastolic BP 72 9 mmHg Prior to pregnancy 22 28 women had been on insulin treatment During pregnancy 74 women 93 were treated with insulin and 11 14 with antihypertensive medication Progression of diabetic retinopathy was observed in 11 14 women Progression was mainly mild but one woman with poor glycaemic control and uncontrolled hypertension progressed from mild retinopathy to sightthreatening retinopathy with proliferations clinically significant macular oedema and impaired vision in both eyes Progression of diabetic retinopathy was associated with a longer duration of diabetes p = 003 and insulin treatment before pregnancy p = 0004Pregnancyinduced deterioration of diabetic retinopathy is well described in type 1 diabetes 1 The risk of progression of diabetic retinopathy during pregnancy is generally regarded to be similar for type 1 and type 2 diabetic patients but data supporting this assumption are few The prevalence and progression of diabetic retinopathy in pregnancy complicated by type 2 diabetes have hardly been investigated hitherto 2 3 4
Keywords: