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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1016/j.asoc.2010.10.004

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1432-0428

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Anaemia in diabetes is there a rationale to TREAT

Authors: M C Thomas M E Cooper K Rossing H H Parving
Publish Date: 2006/04/04
Volume: 49, Issue: 6, Pages: 1151-
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Abstract

Anaemia is a common finding in patients with diabetes particularly in those with overt nephropathy or renal impairment In tertiary clinics at least one outpatient in five with diabetes has anaemia for whom it constitutes a significant additional burdenAnaemia is associated with an increased risk of diabetic complications including nephropathy retinopathy and macrovascular disease Anaemia may also be significant in determining the outcome of heart failure and hypoxiainduced organ damage in diabetes While several factors contribute to the increased prevalence of anaemia in diabetes the failure of the kidney to increase erythropoietin in response to falling haemoglobin appears to be the dominant factor Although there is a clear rationale for correcting anaemia in people with diabetes it remains to be established whether this will lead to improved outcomes Moreover the balance of risks costs and benefits remains to be established in patients with diabetes The Trial to Reduce Cardiovascular Events with Aranesp darbepoetin alpha Therapy TREAT is a randomised controlled trial designed to determine the impact of anaemia correction on mortality and nonfatal cardiovascular events in patients with type 2 diabetes and stage 3–4 nephropathyAnaemia is a common finding in chronic kidney disease CKD affecting over half of all patients 1 Diabetes as the most common single cause of CKD in the Western world is therefore also the most common cause of renal anaemia However anaemia is also more common in diabetic nephropathy than in other renal diseases For example the Third National Health and Nutrition Examination Survey found that people in the general population with diabetes were nearly twice as likely to have anaemia as people without diabetes but with a similar degree of renal impairment 2 Anaemia also develops earlier and is more severe in patients with diabetes than in patients with renal impairment from other causes 3 4

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Other Papers In This Journal:
  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  16. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
  17. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
  18. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
  19. Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas )
  20. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
  21. Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  23. Increased tissue kallikrein levels in type 2 diabetes
  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  25. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
  27. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
  28. WNT/β-catenin increases the production of incretins by entero-endocrine cells
  29. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
  30. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
  31. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
  32. Reply to comment on: Høi-Hansen T, Pedersen-Bjergaard U, Thorsteinsson B (2005) The Somogyi phenomenon revisited using continuous glucose monitoring in daily life. Diabetologia 48:2437–2438
  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
  34. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
  35. Causal interpretation requires appropriate study design. Reply to Priest PC [letter]
  36. Is type 2 diabetes an amyloidosis and does it really matter (to patients)?
  37. The power of numbers
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  39. Potential impact of American Diabetes Association (2000) criteria for diagnosis of gestational diabetes mellitus in Spain
  40. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus
  41. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
  42. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
  43. Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
  44. Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers
  45. Pancreatic safety of GLP-1-based therapeutic agents: further insights from rodent studies?
  46. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
  47. Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes
  48. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency
  49. Harry Keen, 1925–2013
  50. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
  51. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance
  52. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
  53. The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined
  54. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers
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  56. Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721
  57. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
  58. Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats
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  60. The BioBreeding rat diabetes model is infected with Ljungan virus
  61. Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes
  62. Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes
  63. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  64. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  65. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
  66. Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?
  67. N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
  68. Impact of cancer on use of glucose-lowering drug treatment in individuals with diabetes: potential mechanisms. Reply to Pouwer F [letter]
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  71. Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I
  72. Les cellules endothéliales des îlots pancréatiques exercent un effet paracrine sur les cellules à insuline chez le rat: implication physiopathologique pour le diabe`te de type 2
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  74. Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
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  77. Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
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  84. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid
  85. Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721
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  94. Reply to Comment on: Weets I, Kaufman L, Van der Auwera B et al. (2004) Seasonality in clinical onset of Type 1 diabetes in Belgian patients above the age of 10 is restricted to HLA DQ2/DQ8 -negative males, which explains the male to female excess in incidence. Diabetologia 47:614–621
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