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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1007/bf02247485

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1432-0428

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Retinolbinding protein 4 is associated with compo

Authors: M von Eynatten P M Lepper D Liu K Lang M Baumann P P Nawroth A Bierhaus K A Dugi U Heemann B Allolio P M Humpert
Publish Date: 2007/07/18
Volume: 50, Issue: 9, Pages: 1930-1937
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Abstract

Retinolbinding protein 4 RBP4 has recently been reported to be associated with insulin resistance and the metabolic syndrome This study tested the hypothesis that RBP4 is a marker of insulin resistance and the metabolic syndrome in patients with type 2 diabetes or coronary artery disease CAD or in nondiabetic control subjects without CADSerum RBP4 was measured in 365 men 126 with type 2 diabetes 143 with CAD and 96 control subjects and correlated with the homeostasis model assessment of insulin resistance index HOMAIR components of the metabolic syndrome and lipoprotein metabolism RBP4 was detected by ELISA and validated by quantitative Western blottingRBP4 concentrations detected by ELISA were shown to be strongly associated with the results gained in quantitative Western blots There were no associations of RBP4 with HOMAIR or HbA1c in any of the groups studied In patients with type 2 diabetes there were significant positive correlations of RBP4 with total cholesterol LDLcholesterol VLDLcholesterol plasma triacylglycerol and hepatic lipase activity In patients with CAD there were significant associations of RBP4 with VLDLcholesterol plasma triacylglycerol and hepatic lipase activity while nondiabetic control subjects without CAD showed positive correlations of RBP4 with VLDLcholesterol and plasma triacylglycerolRBP4 does not seem to be a valuable marker for identification of the metabolic syndrome or insulin resistance in male patients with type 2 diabetes or CAD Independent associations of RBP4 with proatherogenic lipoproteins and enzymes of lipoprotein metabolism indicate a possible role of RBP4 in lipid metabolism

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  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
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  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
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  32. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
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  49. Harry Keen, 1925–2013
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  52. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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