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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer Berlin Heidelberg

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DOI

10.1007/978-1-4842-0019-3_9

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1432-0428

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Obesity phenotype is related to NLRP3 inflammasome

Authors: Nathalie Esser Laurent L’homme Arnaud De Roover Laurent Kohnen André J Scheen Michel Moutschen Jacques Piette Sylvie LegrandPoels Nicolas Paquot
Publish Date: 2013/09/07
Volume: 56, Issue: 11, Pages: 2487-2497
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Abstract

Obesity is a heterogeneous condition comprising both individuals who remain metabolically healthy MHO and those who develop metabolic disorders metabolically unhealthy MUO Adipose tissue is also heterogeneous in that its visceral component is more frequently associated with metabolic dysfunction than its subcutaneous component The development of metabolic disorders is partly mediated by the NLR family pyrin domain containing3 NLRP3 inflammasome which increases the secretion of inflammatory cytokines via activation of caspase1 We compared the immunological profile and NLRP3 activity in adipose tissue between MUO and MHO individualsMHO and MUO phenotypes were defined respectively as the absence and the presence of the metabolic syndrome Cellular composition and intrinsic inflammasome activity were investigated by flow cytometry quantitative RTPCR and tissue culture studies in subcutaneous and visceral adipose tissue from 23 MUO 21 MHO and nine lean individualsWe found significant differences between the three study groups including an increased secretion of IL1β increased expression of IL1B and NLRP3 increased number of adipose tissue macrophages and decreased number of regulatory T cells in the visceral adipose tissue of MUO patients compared with MHO and lean participants In macrophages derived from visceral adipose tissue both caspase1 activity and IL1β levels were higher in MUO patients than in MHO patients Furthermore caspase1 activity was higher in CD11c+CD206+ adipose tissue macrophages than in CD11c−CD206+ cells

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  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  16. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
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  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  23. Increased tissue kallikrein levels in type 2 diabetes
  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  25. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
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  28. WNT/β-catenin increases the production of incretins by entero-endocrine cells
  29. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
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  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
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  35. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
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  50. Harry Keen, 1925–2013
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  53. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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  64. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
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