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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1002/polb.21677

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1432-0428

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Genomewide scans for heritability of fasting seru

Authors: B I Freedman S S Rich M M Sale G Heiss L Djoussé J S Pankow M A Province D C Rao C E Lewis Y D I Chen S R Beck on behalf of the HyperGEN Investigators
Publish Date: 2005/03/04
Volume: 48, Issue: 4, Pages: 661-668
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Abstract

We calculated the familial aggregation of fasting serum glucose and insulin concentrations and performed a genomewide scan to assess whether quantitative trait loci contribute to these phenotypes in 2412 nondiabetic individuals from 1030 families enrolled in the Hypertension Genetic Epidemiology Network HyperGEN in the Family Blood Pressure ProgramThe heritability ±SE of fasting serum insulin was 047±0085 in European Americans and 028±008 in African Americans p00001 for both after adjusting for age sex and BMI A genomewide scan for fasting serum insulin yielded a maximum log of the odds LOD score of 236 on chromosome 5 at 20 cM p=00004 in European Americans and an LOD score of 228 on chromosome 19 at 11 cM p=00004 in African Americans The heritability of fasting serum glucose was 05109±008 in the former and 029±009 in the latter p00003 for both after adjusting for age sex and BMI A genomewide scan for fasting serum glucose revealed a maximum LOD score of 207 on chromosome 5 at 26 cM p=00009 in European AmericansThese analyses demonstrate the marked heritability of fasting serum insulin and glucose concentrations in families enriched for the presence of members with hypertension They suggest that genes associated with fasting serum insulin concentration are present on chromosomes 19 and 5 and that genes associated with fasting serum glucose concentration are on chromosome 5 in families enriched for hypertension

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  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
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