Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Diabetologia

Search In Journal Title:

Abbravation: Diabetologia

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

ISSN

1432-0428

Search In ISSN:
Search In Title Of Papers:

A serum 25hydroxyvitamin D concentrationassociat

Authors: Rona J Strawbridge Anna Deleskog Olga McLeod Lasse Folkersen Maryam Kavousi Karl Gertow Damiano Baldassarre Fabrizio Veglia Karin Leander Bruna Gigante Jussi Kauhanen Rainer Rauramaa Andries J Smit Elmo Mannarino Philippe Giral Abbas Dehghan Albert Hofman Oscar H Franco Steve E Humphries Elena Tremoli Ulf de Faire Sven Gustafsson ClaesGöran Östensson Per Eriksson John Öhrvik Anders Hamsten
Publish Date: 2014/03/25
Volume: 57, Issue: 6, Pages: 1159-1172
PDF Link

Abstract

The findings of studies investigating whether or not low serum 25hydroxyvitamin D 25OHD concentration promotes development of atherosclerosis have been contradictory The present study employed a Mendelian randomisation approach and carotid artery intima–media thickness cIMT a surrogate marker of coronary artery disease to address this questionThe multicentre longitudinal Carotid Intima–Media Thickness and IMTProgression as Predictors of Vascular Events in a HighRisk European Population IMPROVE cohort study which enrolled individuals with at least three cardiovascular risk factors and no history or symptoms of cardiovascular disease was used for the present investigation Participants underwent carotid ultrasound examination at baseline and at months 15 and 30 Six single nucleotide polymorphisms SNPs associated with serum 25OHD concentration in genomewide association studies were identified and genotyped in 3418 individuals of whom 929 had type 2 diabetesSNPs in the genes encoding vitamin D binding protein GC rs2282679 and rs7041 and 7dehydrocholesterol reductase/NAD synthetase1 DHCR7 rs12785878 and rs3829251 were negatively associated with 25OHD levels Effect sizes and significance of associations between SNPs and 25OHD levels differed between individuals with and without type 2 diabetes although no significant interactions were observed A SNP in DHCR7 interacted with type 2 diabetes to significantly influence progression of cIMT measures independent of 25OHD levels and established risk factors Expression analysis demonstrated that this SNP modulates DHCR7 mRNA levels in aortic adventitiaSNPs in GC and DHCR7 were associated with serum levels of 25OHD but only rs3829251 DHCR7 influenced progression of subclinical atherosclerosis as measured by cIMT in a manner dependent on type 2 diabetes status but independent of 25OHD levels

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  16. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
  17. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
  18. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
  19. Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas )
  20. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
  21. Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  23. Increased tissue kallikrein levels in type 2 diabetes
  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  25. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
  27. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
  28. WNT/β-catenin increases the production of incretins by entero-endocrine cells
  29. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
  30. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
  31. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
  32. Reply to comment on: Høi-Hansen T, Pedersen-Bjergaard U, Thorsteinsson B (2005) The Somogyi phenomenon revisited using continuous glucose monitoring in daily life. Diabetologia 48:2437–2438
  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
  34. Anaemia in diabetes: is there a rationale to TREAT?
  35. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
  36. Causal interpretation requires appropriate study design. Reply to Priest PC [letter]
  37. Is type 2 diabetes an amyloidosis and does it really matter (to patients)?
  38. The power of numbers
  39. Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein
  40. Potential impact of American Diabetes Association (2000) criteria for diagnosis of gestational diabetes mellitus in Spain
  41. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus
  42. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
  43. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
  44. Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
  45. Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers
  46. Pancreatic safety of GLP-1-based therapeutic agents: further insights from rodent studies?
  47. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
  48. Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes
  49. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency
  50. Harry Keen, 1925–2013
  51. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
  52. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance
  53. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
  54. The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined
  55. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers
  56. Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats
  57. Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721
  58. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
  59. Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats
  60. Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost
  61. The BioBreeding rat diabetes model is infected with Ljungan virus
  62. Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes
  63. Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes
  64. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  65. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  66. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
  67. Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?
  68. N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
  69. Impact of cancer on use of glucose-lowering drug treatment in individuals with diabetes: potential mechanisms. Reply to Pouwer F [letter]
  70. Presence of sulphatide (3′-sulphogalactosylceramide) in pericytes in the choroid layer of the eye: sharing of this glycolipid autoantigen with islets of Langerhans
  71. Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice
  72. Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I
  73. Les cellules endothéliales des îlots pancréatiques exercent un effet paracrine sur les cellules à insuline chez le rat: implication physiopathologique pour le diabe`te de type 2
  74. Glucagon responses to increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions in patients with type 2 diabetes and healthy individuals
  75. Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
  76. Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review
  77. Benefit of adjunct corticosteroids for community-acquired pneumonia in diabetic patients
  78. Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
  79. Committed subcutaneous preadipocytes are reduced in human obesity
  80. Hypothalamic obesity
  81. Bone status in adolescents with type 1 diabetes
  82. Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001–2007
  83. Increased aortic stiffness is persistent in type 1 diabetic women: a follow-up study
  84. The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice
  85. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid
  86. Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721
  87. Improved patient survival with simultaneous pancreas and kidney transplantation in recipients with diabetic end-stage renal disease
  88. Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women
  89. Insulin resistance induced by sucrose feeding in rats is due to an impairment of the hepatic parasympathetic nerves
  90. Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
  91. The ultrastructure of the liver reticulo-endothelial cells in diabetics
  92. Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset
  93. Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset
  94. Prospective incidence study of diabetes mellitus in New Zealand children aged 0 to 14 years
  95. Reply to Comment on: Weets I, Kaufman L, Van der Auwera B et al. (2004) Seasonality in clinical onset of Type 1 diabetes in Belgian patients above the age of 10 is restricted to HLA DQ2/DQ8 -negative males, which explains the male to female excess in incidence. Diabetologia 47:614–621
  96. Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase
  97. De novo mutations of GCK , HNF1A and HNF4A may be more frequent in MODY than previously assumed
  98. To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4 : possible link to beta cell regenerative capacity. Diabetologia 48:900–905
  99. Three generations of autoimmune diabetes: an extended family study
  100. Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery
  101. Season-dependent associations of circadian rhythm-regulating loci ( CRY1 , CRY2 and MTNR1B ) and glucose homeostasis: the GLACIER Study
  102. The importance of beta cell characterisation: generating human beta cells by differentiating human embryonic stem cells
  103. SDF-1–CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1–SLIT2 interactions in mice
  104. Silent myocardial infarction and its prognosis in a community-based cohort of Type 2 diabetic patients: the Fremantle Diabetes Study
  105. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes
  106. Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: A new insight into selective nitrergic neuropathy in diabetes
  107. Muscle-specific activation of Ca 2+ /calmodulin-dependent protein kinase IV increases whole-body insulin action in mice
  108. Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes
Search Result: