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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1002/hep.1840040224

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1432-0428

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WNT/βcatenin increases the production of incretin

Authors: J M GarcíaMartínez A ChocarroCalvo C M Moya C GarcíaJiménez
Publish Date: 2009/07/07
Volume: 52, Issue: 9, Pages: 1913-1924
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Abstract

Glucosedependent insulinotropic peptide GIP plays a pivotal role in the regulation of glucose homeostasis Rates of dietinduced obesity insulin resistance and type 2 diabetes are decreased when GIP signalling is disturbed in mice suggesting that GIP plays a role in the onset of type 2 diabetes WNT signalling is linked to type 2 diabetes and induces synthesis of the other incretin glucagonlike peptide 1 GLP1 GLP1 analogues improve treatment of type 2 diabetes patients in whom GLP1 signalling is intact and have captured clinical attention GIP levels are altered at the onset of type 2 diabetes and later on while GIP signalling is impaired Thus GIP is not a candidate for treatment but might be an important target from a prevention perspective Hypothesising that hypersecretion of GIP links altered WNT signalling to the onset of type 2 diabetes we sought to determine whether WNT signalling induces GIP production by enteroendocrine cellsLithium or WNT/βcatenin signalling enhanced GIP production by enteroendocrine cells through a conserved site in the proximal Gip promoter Lithium favours lymphoid enhancer factor1/βcatenin binding to Gip promoter and diminishes ChIP through T cell factor4 and histone deacetylase 1

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  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
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  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  16. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
  17. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
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  20. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
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  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  23. Increased tissue kallikrein levels in type 2 diabetes
  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  25. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
  27. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
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  29. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
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  32. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
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  34. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
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  42. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
  43. Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
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  49. Harry Keen, 1925–2013
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  51. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance
  52. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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  56. Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721
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