Authors: Shristi Rawal Stefanie N Hinkle Wei Bao Yeyi Zhu Jagteshwar Grewal Paul S Albert Natalie L Weir Michael Y Tsai Cuilin Zhang
Publish Date: 2016/11/10
Volume: 60, Issue: 2, Pages: 249-257
Abstract
The aim of this study was to prospectively and longitudinally investigate maternal iron status during early to midpregnancy and subsequent risk of gestational diabetes mellitus GDM using a comprehensive panel of conventional and novel iron biomarkersA case–control study of 107 women with GDM and 214 controls matched on age race/ethnicity and gestational week during blood collection was conducted within the the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies–Singleton Cohort 2009–2013 a prospective and multiracial pregnancy cohort Plasma hepcidin ferritin and soluble transferrin receptor sTfR were measured and sTfRferritin ratio was derived twice before GDM diagnosis gestational weeks 10–14 and 15–26 and at weeks 23–31 and 33–39 GDM diagnosis was ascertained from medical records Adjusted ORs aORs for GDM were estimated using conditional logistic regression analysis adjusting for demographics prepregnancy BMI and other major risk factorsHepcidin concentrations during weeks 15–26 were 16 higher among women with GDM vs controls median 64 vs 55 ng/ml p = 002 and were positively associated with GDM risk the aOR 95 CI for highest vs lowest quartile was 261 107 636 Ferritin levels were also positively associated with GDM risk the aOR 95 CI for highest vs lowest quartile was 243 112 528 at weeks 10–14 and 395 138 1130 at weeks 15–26 The sTfRferritin ratio was inversely related to GDM risk the aOR 95 CI for highest vs lowest quartile was 033 014 080 at weeks 10–14 and 015 005 048 at weeks 15–26
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