Authors: T HøiHansen U PedersenBjergaard B Thorsteinsson
Publish Date: 2006/05/20
Volume: 49, Issue: 7, Pages: 1708-1709
Abstract
Fasting morning glucose concentrations measured by selfmonitored blood glucose and CGMS and hourly postbreakfast glucose concentrations measured by CGMS for 4 h The data are shown as means ± SEM Black diamonds with nocturnal hypoglycaemia nadir CGMS=22 mmol/l black squares possible nocturnal hypoglycaemia nadir CGMS=23–35 mmol/l open circles without nocturnal hypoglycaemia nadir CGMS 35 mmol/lIn our research letter we reported a significant difference in mean fasting morning blood glucose between nights without hypoglycaemia and the other two categories of glycaemia 5 Similarly we found that 1 h after measurement of fasting morning blood glucose the mean glucose value for nights without hypoglycaemia mean ± SEM 119±03 mmol/l was significantly different from that for possible hypoglycaemic nights 98±06 mmol/l p0003 Bonferroni corrected and that for hypoglycaemic nights 103±04 mmol/l p0006 Bonferroni corrected After 2 3 and 4 h there were no significant differences between the three categories Maximum glucose values for days after nights without hypoglycaemia with possible hypoglycaemia and with hypoglycaemia were 161±04 146±06 and 162±04 mmol/l p=098 and p=081 for without hypoglycaemia vs possible hypoglycaemia and with hypoglycaemia respectively These results show that the glucose concentration levels out after fasting morning blood glucose They do not support the proposal that high glucose values during late morning are an indicator of previous hypoglycaemic nights In conclusion in type 1 diabetes nocturnal hypoglycaemia should be suspected in the case of low fasting glucose values in the morning Hyperglycaemia fasting or later during the day should not be regarded as an indicator of previous nocturnal hypoglycaemic episodes
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