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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1002/chin.199142283

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1432-0428

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Increased aortic stiffness is persistent in type 1

Authors: Å R Ahlgren H Åstrand G Sundkvist T Länne
Publish Date: 2005/03/04
Volume: 48, Issue: 4, Pages: 780-783
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Abstract

We have previously reported that women not men with type 1 diabetes have increased aortic stiffness Increased arterial stiffness may explain why diabetic women have a particularly high risk of developing cardiovascular complications We have now followed up our previously investigated patients after 7 years with a view to evaluating whether the sex difference was persistent and also evaluating the degree of progression with time and the relationship between stiffness versus intima media thickness of the aortaAt followup aortic stiffness was still higher 60 p=00016 in diabetic than in control women whereas there was no similar difference p=04 between diabetic and control men No progression of stiffness had occurred over the 7 years At followup the intima media thickness was increased and the internal diameter of the aorta was decreased in diabetic men and women without any sexrelated differenceThe increased aortic stiffness that affects type 1 diabetic patients seems to be an early event that soon reaches a plateau without any further increase Increased aortic stiffness in type 1 diabetic women seems to be a sexspecific functional disorder unrelated to the degree of underlying atherosclerosisDiabetic patients show an increased risk of cardiovascular complications particularly women patients We have previously shown that women but not men with type 1 diabetes have increased aortic stiffness 1 which may contribute to the increased risk of cardiovascular complications among such women The aims of this followup study were 1 to evaluate whether sexrelated differences in aortic stiffness were persistent 7 years after their first examination and 2 to evaluate the relationship between intima media thickness a marker of atherosclerosis and aortic stiffness

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  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
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  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
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  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
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  50. Harry Keen, 1925–2013
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  53. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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