Authors: J P Lindahl A Hartmann R Horneland H Holdaas A V Reisæter K Midtvedt T Leivestad O Øyen T Jenssen
Publish Date: 2013/04/03
Volume: 56, Issue: 6, Pages: 1364-1371
Abstract
Followup data were retrieved for all 630 patients with diabetic ESRD who had received SPK or KTA at our centre from 1983 to the end of 2010 Recipients younger than 55 years of age received either an SPK n = 222 or if available a single live donor kidney LDK n = 171 Older recipients and recipients with greater comorbidity received a single deceased donor kidney DDK n = 237 Survival was analysed by the Kaplan–Meier method and in multivariate Cox regression analysis adjusting for recipient and donor characteristicsPatient survival was superior in SPK compared with both LDK and DDK recipients in univariate analysis Followup time mean ± SD after transplantation was 71 ± 57 years Median actuarial patient survival was 140 years for SPK 115 years for LDK and 67 years for DDK recipients In multivariate analyses including recipient age sex treatment modality time on dialysis and era SPK transplantation was protective for allcause mortality compared with both LDK p = 002 and DDK p = 0029 transplantation After the year 2000 overall patient survival improved compared with previous years HR 040 95 CI 030 055 p 0001 Pancreas graft survival also improved after 2000 with a 5 year graft survival rate of 78 vs 61 in previous years 1988–1999
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