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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1007/bf02717996

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1432-0428

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Relationship between diabetes risk and admixture i

Authors: L Qi R Nassir R Kosoy L Garcia J D Curb L Tinker B V Howard J Robbins M F Seldin
Publish Date: 2012/02/10
Volume: 55, Issue: 5, Pages: 1329-1337
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Abstract

We estimated the proportion of subSaharan African AFR Amerindian AMI and European admixture using 92 ancestryinformative marker genotypes in 16476 AFA and HA women from the Women’s Health Initiative Cox regression models were used to examine the association between admixture and diabetes risk with and without accounting for socioeconomic status SES and adiposity measurementsAFR admixture was significantly associated with diabetes risk in AFA women when adjusting for entry age neighbourhood SES and BMI or waist/hip ratio WHR all p  00001 In HA women AMI admixture had significant associations with diabetes risk that remained significant after adjustment for SES and BMI all p  00005 In both AFAs and HAs SES showed significant negative associations while BMI or WHR had significant positive associations with diabetes risk with and without adjustment for genetic admixtureIn AFAs admixture SES and BMI/WHR each independently contribute to diabetes risk after accounting for each of the other factors in HAs admixture SES and BMI each independently contribute to diabetes risk after accounting for each of the other factors whereas admixture is not significantly associated with diabetes risk after accounting for SES and WHR The findings emphasise the importance of considering both genetic and environmental causes in the aetiology of type 2 diabetes

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  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  16. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
  17. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
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  19. Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas )
  20. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
  21. Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  23. Increased tissue kallikrein levels in type 2 diabetes
  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  25. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
  27. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
  28. WNT/β-catenin increases the production of incretins by entero-endocrine cells
  29. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
  30. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
  31. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
  32. Reply to comment on: Høi-Hansen T, Pedersen-Bjergaard U, Thorsteinsson B (2005) The Somogyi phenomenon revisited using continuous glucose monitoring in daily life. Diabetologia 48:2437–2438
  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
  34. Anaemia in diabetes: is there a rationale to TREAT?
  35. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
  36. Causal interpretation requires appropriate study design. Reply to Priest PC [letter]
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  41. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus
  42. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
  43. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
  44. Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
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  47. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
  48. Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes
  49. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency
  50. Harry Keen, 1925–2013
  51. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
  52. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance
  53. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
  54. The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined
  55. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers
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  57. Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721
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  63. Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes
  64. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  65. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  66. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
  67. Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?
  68. N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
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  86. Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721
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