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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1002/anie.198203771

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1432-0428

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Müller glial dysfunction during diabetic retinopat

Authors: T M Curtis R Hamilton PH Yong C M McVicar A Berner R Pringle K Uchida R Nagai S Brockbank A W Stitt
Publish Date: 2010/11/30
Volume: 54, Issue: 3, Pages: 690-698
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Abstract

The impact of AGEs and advanced lipoxidation endproducts ALEs on neuronal and Müller glial dysfunction in the diabetic retina is not well understood We therefore sought to identify dysfunction of the retinal Müller glia during diabetes and to determine whether inhibition of AGEs/ALEs can prevent itSprague–Dawley rats were divided into three groups 1 nondiabetic 2 untreated streptozotocininduced diabetic and 3 diabetic treated with the AGE/ALE inhibitor pyridoxamine for the duration of diabetes Rats were killed and their retinas were evaluated for neuroglial pathologyAGEs and ALEs accumulated at higher levels in diabetic retinas than in controls p  0001 AGE/ALE immunoreactivity was significantly diminished by pyridoxamine treatment of diabetic rats Diabetes was also associated with the upregulation of the oxidative stress marker haemoxygenase1 and the induction of glial fibrillary acidic protein production in Müller glia p  0001 Pyridoxamine treatment of diabetic rats had a significant beneficial effect on both variables p  0001 Diabetes also significantly altered the normal localisation of the potassium inwardly rectifying channel Kir41 and the water channel aquaporin 4 to the Müller glia endfeet interacting with retinal capillaries These abnormalities were prevented by pyridoxamine treatment

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  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
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  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
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  29. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
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  34. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
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  52. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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