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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer Berlin Heidelberg

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DOI

10.1016/0003-9861(72)90438-9

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1432-0428

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The power of numbers

Authors: Marco Dauriz James B Meigs
Publish Date: 2016/04/26
Volume: 59, Issue: 7, Pages: 1400-1402
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Abstract

The study of human genetic variation represents a major chapter in the history of modern medicine and still holds the fascinating promise of identifying the genetic architecture of a large number of disease traits 1 2 This is particularly relevant nowadays in light of the prospective rising trends in the global incidence and prevalence of type 2 diabetes 3 However the noncommunicable diseases such as type 2 diabetes carry a considerable burden of complexity as a result of the combination of genetic epigenetic and environmental risk factors 4 which complicate the understanding of type 2 diabetes genetic background and its potential clinical transferability in terms of prognostic and preventive rules or potentially novel drug targetsThe technical and methodological advancements as well as the knowledge accrued over the past decade on the haplotype block structure of the human genome 1 5 have enabled investigators to tackle the complexity of the genetic architecture of type 2 diabetes in populations of European and nonEuropean descent by performing largescale genomewide association studies GWAS for both common and rare genetic variants 2 6 To date the international research consortia leading these initiatives have identified over 90 genetic loci credibly associated with a higher risk of type 2 diabetes and more are expected in the years to come When considered in aggregate the loci identified explain only a limited proportion of the type 2 diabetes liabilityscale variance possibly because the total number of the entire spectrum of type 2 diabetes risk loci has yet to be identified or because the causal variants harbored in or near these loci as well as the underlying biological pathways remain to be elucidated in most instances

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Other Papers In This Journal:
  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  16. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
  17. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
  18. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
  19. Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas )
  20. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
  21. Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  23. Increased tissue kallikrein levels in type 2 diabetes
  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  25. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
  27. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
  28. WNT/β-catenin increases the production of incretins by entero-endocrine cells
  29. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
  30. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
  31. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
  32. Reply to comment on: Høi-Hansen T, Pedersen-Bjergaard U, Thorsteinsson B (2005) The Somogyi phenomenon revisited using continuous glucose monitoring in daily life. Diabetologia 48:2437–2438
  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
  34. Anaemia in diabetes: is there a rationale to TREAT?
  35. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
  36. Causal interpretation requires appropriate study design. Reply to Priest PC [letter]
  37. Is type 2 diabetes an amyloidosis and does it really matter (to patients)?
  38. Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein
  39. Potential impact of American Diabetes Association (2000) criteria for diagnosis of gestational diabetes mellitus in Spain
  40. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus
  41. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
  42. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
  43. Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
  44. Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers
  45. Pancreatic safety of GLP-1-based therapeutic agents: further insights from rodent studies?
  46. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
  47. Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes
  48. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency
  49. Harry Keen, 1925–2013
  50. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
  51. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance
  52. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
  53. The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined
  54. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers
  55. Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats
  56. Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721
  57. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
  58. Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats
  59. Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost
  60. The BioBreeding rat diabetes model is infected with Ljungan virus
  61. Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes
  62. Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes
  63. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  64. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  65. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
  66. Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?
  67. N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
  68. Impact of cancer on use of glucose-lowering drug treatment in individuals with diabetes: potential mechanisms. Reply to Pouwer F [letter]
  69. Presence of sulphatide (3′-sulphogalactosylceramide) in pericytes in the choroid layer of the eye: sharing of this glycolipid autoantigen with islets of Langerhans
  70. Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice
  71. Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I
  72. Les cellules endothéliales des îlots pancréatiques exercent un effet paracrine sur les cellules à insuline chez le rat: implication physiopathologique pour le diabe`te de type 2
  73. Glucagon responses to increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions in patients with type 2 diabetes and healthy individuals
  74. Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
  75. Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review
  76. Benefit of adjunct corticosteroids for community-acquired pneumonia in diabetic patients
  77. Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
  78. Committed subcutaneous preadipocytes are reduced in human obesity
  79. Hypothalamic obesity
  80. Bone status in adolescents with type 1 diabetes
  81. Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001–2007
  82. Increased aortic stiffness is persistent in type 1 diabetic women: a follow-up study
  83. The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice
  84. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid
  85. Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721
  86. Improved patient survival with simultaneous pancreas and kidney transplantation in recipients with diabetic end-stage renal disease
  87. Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women
  88. Insulin resistance induced by sucrose feeding in rats is due to an impairment of the hepatic parasympathetic nerves
  89. Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
  90. The ultrastructure of the liver reticulo-endothelial cells in diabetics
  91. Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset
  92. Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset
  93. Prospective incidence study of diabetes mellitus in New Zealand children aged 0 to 14 years
  94. Reply to Comment on: Weets I, Kaufman L, Van der Auwera B et al. (2004) Seasonality in clinical onset of Type 1 diabetes in Belgian patients above the age of 10 is restricted to HLA DQ2/DQ8 -negative males, which explains the male to female excess in incidence. Diabetologia 47:614–621
  95. A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)
  96. Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase
  97. De novo mutations of GCK , HNF1A and HNF4A may be more frequent in MODY than previously assumed
  98. To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4 : possible link to beta cell regenerative capacity. Diabetologia 48:900–905
  99. Three generations of autoimmune diabetes: an extended family study
  100. Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery
  101. Season-dependent associations of circadian rhythm-regulating loci ( CRY1 , CRY2 and MTNR1B ) and glucose homeostasis: the GLACIER Study
  102. The importance of beta cell characterisation: generating human beta cells by differentiating human embryonic stem cells
  103. SDF-1–CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1–SLIT2 interactions in mice
  104. Silent myocardial infarction and its prognosis in a community-based cohort of Type 2 diabetic patients: the Fremantle Diabetes Study
  105. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes
  106. Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: A new insight into selective nitrergic neuropathy in diabetes
  107. Muscle-specific activation of Ca 2+ /calmodulin-dependent protein kinase IV increases whole-body insulin action in mice
  108. Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes
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