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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer Berlin Heidelberg

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DOI

10.1007/s00221-015-4518-z

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1432-0428

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Insulitis and characterisation of infiltrating T c

Authors: Lars Krogvold Anna Wiberg Bjørn Edwin Trond Buanes Frode Lars Jahnsen Kristian F Hanssen Erik Larsson Olle Korsgren Oskar Skog Knut DahlJørgensen
Publish Date: 2015/11/24
Volume: 59, Issue: 3, Pages: 492-501
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Abstract

It is thought that T cells play a major role in the immunemediated destruction of beta cells in type 1 diabetes causing inflammation of the islets of Langerhans insulitis The significance of insulitis at the onset of type 1 diabetes is debated and the role of the T cells poorly understoodIn the Diabetes Virus Detection DiViD study pancreatic tissue from six living patients with recentonset type 1 diabetes was collected The insulitis was characterised quantitatively by counting CD3+ T cells and qualitatively by transcriptome analysis targeting 84 T and B lymphocyte genes of lasercaptured microdissected islets The findings were compared with gene expression in T cells collected from kidney biopsies from allografts with ongoing cellular rejection Cytokine and chemokine release from isolated islets was characterised and compared with that from islets from nondiabetic organ donorsAll six patients fulfilled the criteria for insulitis 5–58 of the insulincontaining islets in the six patients had ≥ 15 T cells/islet Of all the islets 36 contained insulin with several resembling completely normal islets The majority 61–83 of T cells were found as periinsulitis rather than within the islet parenchyma The expression pattern of T cell genes was found to be markedly different in islets compared with the rejected kidneys The isletinfiltrating T cells showed only background levels of cytokine/chemokine release in vitroInsulitis and a significant reserve reservoir for insulin production were present in all six cases of recentonset type 1 diabetes Furthermore the expression patterns and levels of cytokines argue for a different role of the T cells in type 1 diabetes when compared with allograft rejection

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  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
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  20. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
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  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
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  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
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  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
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  35. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
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  47. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
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  50. Harry Keen, 1925–2013
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  53. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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