Authors: S Suzuki M Koga S Amamiya A Nakao K Wada K Okuhara S Hayano A R Sarhat H Takahashi K Matsuo Y Tanahashi K Fujieda
Publish Date: 2011/06/05
Volume: 54, Issue: 9, Pages: 2247-
Abstract
It is difficult to use HbA1c as an indicator of glycaemic control in patients with neonatal diabetes mellitus NDM because of high levels of fetal haemoglobin HbF remaining in the blood In this study glycated albumin GA which is not affected by HbF and HbA1c were compared to evaluate whether they reflect glycaemic control in patients with NDMThis study included five patients with NDM Age at diagnosis was 38 ± 20 days Insulin therapy was started in all patients and levels of GA HbA1c and HbF were measured monthly for 6 months Onemonth average preprandial plasma glucose aPPG was calculated using selfmonitoring of blood glucosePlasma glucose and GA were elevated 297 ± 131 mmol/l n = 5 and 333 ± 69 n = 3 respectively but HbA1c was within normal limits 54 ± 26 355 ± 49 mmol/mol n = 4 at diagnosis With diabetes treatment aPPG r = −0565 p = 0002 GA r = −0552 p = 0003 and HbF r = −0855 p 00001 decreased with age whereas HbA1c increased r = 0449 p = 0004 GA was strongly positively correlated with aPPG r = 0784 p 00001 while HbA1c showed no correlation with aPPG r = 0221 p = 0257 and was significantly inversely correlated with HbF r = −0539 p = 0004
Keywords: