Authors: Lia Bally Thomas Zueger Tania Buehler Ayse S Dokumaci Christian Speck Nicola Pasi Carlos Ciller Daniela Paganini Katrin Feller Hannah Loher Robin Rosset Matthias Wilhelm Luc Tappy Chris Boesch Christoph Stettler
Publish Date: 2016/01/06
Volume: 59, Issue: 4, Pages: 776-784
Abstract
In a prospective randomised openlabel crossover trial twelve male individuals with wellcontrolled type 1 diabetes underwent a 90 min isoenergetic cycling session at 50 maximal oxygen consumption oversetcdot VmathrmO 2 max with IHE or without CONT interspersed 10 s sprints every 10 min without insulin adaptation Euglycaemia was maintained using oral 13Clabelled glucose 13C Magnetic resonance spectroscopy MRS served to quantify hepatocellular and intramyocellular glycogen Measurements of glucose kinetics stable isotopes hormones and metabolites complemented the investigationGlucose and insulin levels were comparable between interventions Exogenous glucose requirements during the last 30 min of exercise were significantly lower in IHE p = 002 Hepatic glucose output did not differ significantly between interventions but glucose disposal was significantly lower in IHE p 005 There was no significant difference in glycogen consumption Growth hormone catecholamine and lactate levels were significantly higher in IHE p 005IHE in individuals with type 1 diabetes without insulin adaptation reduced exogenous glucose requirements compared with CONT The difference was not related to increased hepatic glucose output nor to enhanced muscle glycogen utilisation but to decreased glucose uptake The lower glucose disposal in IHE implies a shift towards consumption of alternative substrates These findings indicate a high flexibility of exerciserelated fuel metabolism in type 1 diabetes and point towards a novel and potentially beneficial role of IHE in these individuals
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