Authors: Wendy A Davis Renate R Zilkens Sergio E Starkstein Timothy M E Davis David G Bruce
Publish Date: 2016/10/07
Volume: 60, Issue: 1, Pages: 89-97
Abstract
A longitudinal observational study was undertaken involving 1291 participants with type 2 diabetes from the Fremantle Diabetes Study and 5159 matched residents without documented diabetes Linkage with healthrelated databases was used to detect incident dementia Relative hazards were assessed using both causespecific and subdistribution proportional hazards modelsDuring 138 ± 58 years of followup incident dementia occurred in 139 and 124 of the groups of participants with and without diabetes respectively p = 015 With type 2 diabetes the incidence of dementia was higher incidence rate ratio IRR 128 95 CI 108 151 as was the competing risk of death IRR 150 95 CI 138 164 The ages when dementia was first recorded and when death with dementia occurred were both earlier with diabetes by 17 95 CI 06 29 and 23 95 CI 11 36 years respectively both p ≤ 0004 Type 2 diabetes was associated with an adjusted subdistribution HR of 118 95 CI 100 139 and a causespecific HR of 151 95 CI 127 178 for allcause dementiaType 2 diabetes is associated with an increased incidence of dementia and dementia onset occurs at a younger age The relative hazards of both dementia and premature mortality are increased and as a consequence the increased risk of dementia in type 2 diabetes is not as marked as suggested by causespecific HRs
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