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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1016/0030-3992(78)90100-7

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1432-0428

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R Tattersall Diabetes the biography Oxford Uni

Authors: V Jörgens
Publish Date: 2010/02/02
Volume: 53, Issue: 5, Pages: 1009-1010
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Abstract

It was a pleasure to read Diabetes the biography Robert Tattersall has been working for many years as he mentions in the preface on a definitive and exhaustive history of diabetes and the academic world of diabetes has been looking forward to his magnum opus He has now published a biography of diabetes with a minimum of references for a wide general readership Nevertheless the book is very interesting to read not only for socalled lay persons but also for diabetes specialists as Robert Tattersall addresses many issues and tells many stories that are not mentioned in the sometimes boring academic books and articles on the history of diabetesRarely has the history of the discovery of insulin been summarised in such a balanced way Tattersall also points out the major contributions of Macleod and the biochemist Collip to this discovery There are many historical books on diabetes but what makes Tattersall’s book outstanding is his detailed discussion of the more recent history of diabetes research and care Who knows that metformin was developed from Galega officinalis All the ups and downs of di and biguanides and sulfonylureas over the decades are described in detail The design and outcome of the University Group Diabetes Programme which was the first endpoint trial on diabetes treatment are critiqued It is particularly interesting to read the chapter on selfmonitoring of blood glucose since the author himself was one of the first to introduce monitoring and thus actively involve the person with diabetes in his or her treatment Nor does he forget to mention the story of Richard K Bernstein who noticed the importance of blood glucose monitoring in treating his own diabetes while the company that invented Dextrostix in 1964 missed the opportunity to gain a world market being exclusively focused on physicians Another very interesting chapter is the debate that went on for decades on the question of whether good metabolic control prevents complications which was finally resolved by the DCCT and UK Prospective Diabetes Study UKPDSBecause Robert Tattersall has such a profound knowledge of the history of diabetes it is very difficult to find a mistake in the book even the contributions of German diabetologists such as Professor Stolte from Breslau who instigated ‘dose adjustment for normal eating’ are reported correctly However it is debatable as to who introduced the insulin pump Tattersall mentions only H Keen and J Pickup Based upon personal reports I think it was H Keen and K G M M Alberti who initiated the use of the Mill Hill pump for subcutaneous insulin treatment although the young doctor Pickup later devoted his career to this idea Only the name of Paul Kimmelstiel is misspelt he was born in Hamburg emigrated in 1933 to the USA where he met Clifford Wilson and published a famous paper on diabetic nephropathy The obituary for Paul Kimmelstiel by Philippe M Leconte in Diabetes in 1971 1 ends with the sentence ‘Seldom has anyone been so severely afflicted with the libido sciendi’ Tattersall’s book should be offered to young diabetologists it would certainly increase their ‘libido sciendi’ and widen their critical view on clinical diabetes research


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  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  15. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  16. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
  17. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
  18. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
  19. Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas )
  20. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
  21. Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
  22. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  23. Increased tissue kallikrein levels in type 2 diabetes
  24. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  25. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  26. An RBP4 promoter polymorphism increases risk of type 2 diabetes
  27. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
  28. WNT/β-catenin increases the production of incretins by entero-endocrine cells
  29. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
  30. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
  31. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
  32. Reply to comment on: Høi-Hansen T, Pedersen-Bjergaard U, Thorsteinsson B (2005) The Somogyi phenomenon revisited using continuous glucose monitoring in daily life. Diabetologia 48:2437–2438
  33. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
  34. Anaemia in diabetes: is there a rationale to TREAT?
  35. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
  36. Causal interpretation requires appropriate study design. Reply to Priest PC [letter]
  37. Is type 2 diabetes an amyloidosis and does it really matter (to patients)?
  38. The power of numbers
  39. Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein
  40. Potential impact of American Diabetes Association (2000) criteria for diagnosis of gestational diabetes mellitus in Spain
  41. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus
  42. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
  43. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
  44. Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
  45. Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers
  46. Pancreatic safety of GLP-1-based therapeutic agents: further insights from rodent studies?
  47. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
  48. Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes
  49. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency
  50. Harry Keen, 1925–2013
  51. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
  52. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance
  53. The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined
  54. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers
  55. Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats
  56. Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721
  57. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
  58. Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats
  59. Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost
  60. The BioBreeding rat diabetes model is infected with Ljungan virus
  61. Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes
  62. Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes
  63. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  64. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  65. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
  66. Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?
  67. N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
  68. Impact of cancer on use of glucose-lowering drug treatment in individuals with diabetes: potential mechanisms. Reply to Pouwer F [letter]
  69. Presence of sulphatide (3′-sulphogalactosylceramide) in pericytes in the choroid layer of the eye: sharing of this glycolipid autoantigen with islets of Langerhans
  70. Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice
  71. Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I
  72. Les cellules endothéliales des îlots pancréatiques exercent un effet paracrine sur les cellules à insuline chez le rat: implication physiopathologique pour le diabe`te de type 2
  73. Glucagon responses to increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions in patients with type 2 diabetes and healthy individuals
  74. Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
  75. Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review
  76. Benefit of adjunct corticosteroids for community-acquired pneumonia in diabetic patients
  77. Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
  78. Committed subcutaneous preadipocytes are reduced in human obesity
  79. Hypothalamic obesity
  80. Bone status in adolescents with type 1 diabetes
  81. Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001–2007
  82. Increased aortic stiffness is persistent in type 1 diabetic women: a follow-up study
  83. The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice
  84. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid
  85. Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721
  86. Improved patient survival with simultaneous pancreas and kidney transplantation in recipients with diabetic end-stage renal disease
  87. Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women
  88. Insulin resistance induced by sucrose feeding in rats is due to an impairment of the hepatic parasympathetic nerves
  89. Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
  90. The ultrastructure of the liver reticulo-endothelial cells in diabetics
  91. Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset
  92. Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset
  93. Prospective incidence study of diabetes mellitus in New Zealand children aged 0 to 14 years
  94. Reply to Comment on: Weets I, Kaufman L, Van der Auwera B et al. (2004) Seasonality in clinical onset of Type 1 diabetes in Belgian patients above the age of 10 is restricted to HLA DQ2/DQ8 -negative males, which explains the male to female excess in incidence. Diabetologia 47:614–621
  95. A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)
  96. Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase
  97. De novo mutations of GCK , HNF1A and HNF4A may be more frequent in MODY than previously assumed
  98. To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4 : possible link to beta cell regenerative capacity. Diabetologia 48:900–905
  99. Three generations of autoimmune diabetes: an extended family study
  100. Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery
  101. Season-dependent associations of circadian rhythm-regulating loci ( CRY1 , CRY2 and MTNR1B ) and glucose homeostasis: the GLACIER Study
  102. The importance of beta cell characterisation: generating human beta cells by differentiating human embryonic stem cells
  103. SDF-1–CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1–SLIT2 interactions in mice
  104. Silent myocardial infarction and its prognosis in a community-based cohort of Type 2 diabetic patients: the Fremantle Diabetes Study
  105. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes
  106. Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: A new insight into selective nitrergic neuropathy in diabetes
  107. Muscle-specific activation of Ca 2+ /calmodulin-dependent protein kinase IV increases whole-body insulin action in mice
  108. Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

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