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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer Berlin Heidelberg

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DOI

10.1016/0956-716X(91)90230-X

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1432-0428

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Lowdensitylipoprotein cholesterol concentrations

Authors: Charlotte Andersson Asya Lyass Martin G Larson Sander J Robins Ramachandran S Vasan
Publish Date: 2015/09/26
Volume: 58, Issue: 12, Pages: 2774-2780
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Abstract

Statins and niacin nicotinic acid reduce circulating LDLcholesterol LDLC levels by different mechanisms Yet both increase the risk of diabetes mellitus Our objective was to relate blood LDLC concentrations and a genetic risk score GRS for LDLC to the risk of incident diabetes in individuals not treated with lipidmodifying therapyWe evaluated participants of the Framingham Heart Study who attended any of Offspring cohort examination cycles 3–8 and Third Generation cohort examination cycle 1 N =14120 personobservations 6011 unique individuals mean age 50 ± 11 years 56 women who were not treated with lipidmodifying or antihypertensive medications and who were free from cardiovascular disease at baseline Incident diabetes was assessed at the next examinationThe GRS was significantly associated with LDLC concentrations sex and ageadjusted estimated influence 024 p  00001 On followup mean 45 ± 15 years 312 individuals 22 developed newonset diabetes In multivariable models a higher LDLC concentration was associated with lower risk of diabetes OR per SD increment 081 95 CI 070 093 p = 0004 The GRS was associated with incident diabetes in a similar direction and of comparable magnitude OR per SD increment 085 95 CI 076 096 p = 0009Among individuals not treated with lipidmodifying therapy low LDLC concentrations were associated with increased diabetes risk These observations may contribute to our understanding of why lipidlowering treatment may cause diabetes in some individuals Additional studies are warranted to elucidate the molecular mechanisms underlying our observations

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  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Glycated albumin but not HbA 1c reflects glycaemic control in patients with neonatal diabetes mellitus
  3. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  7. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  8. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  9. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  10. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  11. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
  14. Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise
  15. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
  16. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
  17. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
  18. Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas )
  19. Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study
  20. Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
  21. Induction of the chemokine interferon-γ-inducible protein-10 in human pancreatic islets during enterovirus infection
  22. Increased tissue kallikrein levels in type 2 diabetes
  23. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  24. The response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjects
  25. An RBP4 promoter polymorphism increases risk of type 2 diabetes
  26. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products
  27. WNT/β-catenin increases the production of incretins by entero-endocrine cells
  28. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
  29. Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
  30. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
  31. Reply to comment on: Høi-Hansen T, Pedersen-Bjergaard U, Thorsteinsson B (2005) The Somogyi phenomenon revisited using continuous glucose monitoring in daily life. Diabetologia 48:2437–2438
  32. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
  33. Anaemia in diabetes: is there a rationale to TREAT?
  34. —to: Hales CN, Ozanne SE (2003) For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia 46:1013–1019
  35. Causal interpretation requires appropriate study design. Reply to Priest PC [letter]
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  40. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus
  41. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
  42. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity
  43. Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver
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  46. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort
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  48. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency
  49. Harry Keen, 1925–2013
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  51. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance
  52. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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  56. Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721
  57. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
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  60. The BioBreeding rat diabetes model is infected with Ljungan virus
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  62. Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes
  63. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  64. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
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  66. Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?
  67. N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
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  78. Committed subcutaneous preadipocytes are reduced in human obesity
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  85. Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721
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  94. Reply to Comment on: Weets I, Kaufman L, Van der Auwera B et al. (2004) Seasonality in clinical onset of Type 1 diabetes in Belgian patients above the age of 10 is restricted to HLA DQ2/DQ8 -negative males, which explains the male to female excess in incidence. Diabetologia 47:614–621
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