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Title of Journal: Diabetologia

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Abbravation: Diabetologia

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Springer-Verlag

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DOI

10.1002/chin.198928302

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1432-0428

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Bone status in adolescents with type 1 diabetes

Authors: A P Chobot A Haffke J Polanska Z P Halaba G Deja P JaroszChobot W Pluskiewicz
Publish Date: 2010/05/09
Volume: 53, Issue: 8, Pages: 1754-1760
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Abstract

The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound QUS and the influence of metabolic control and other diseaserelated and growth variables was analysedGroup I consisted of 99 pubertal Tanner ≥2 adolescents 49 female aged 143 ± 25 years diabetes duration 46 ± 23 years Controls group II were 297 children matched by sex and age from a healthy population The influence of glycated haemoglobin current HbA1cD last year’s mean HbA1cY whole duration mean HbA1cT diabetes duration percentage of life with disease and daily insulin requirement DIR on amplitude dependent speed of sound AdSoS at distal phalanges was studiedIn comparison to the control group adolescents with type 1 diabetes presented significantly higher BMI SDS 082 95 CI 054 110 vs −006 95 CI −016 004 p  0001 and lower AdSoS SDS −034 95 CI −057 −011 vs −003 95 CI −015 008 p  005 No correlation between AdSoS SDS and sex DIR or diabetes duration was observed The lower AdSoS SDS reflects reduced bone status and the reduction was significantly more marked in those patients whose HbA1cT was higher than 70 when compared with those whose HbA1cT was lower

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  4. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  5. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus
  6. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  7. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  8. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
  10. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
  11. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes
  12. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  13. Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients
  14. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease
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  50. Harry Keen, 1925–2013
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  53. R. Tattersall. Diabetes: the biography. Oxford University Press, Oxford, 2009
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