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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Kluwer Academic Publishers-Plenum Publishers

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DOI

10.1002/andp.19384230401

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ISSN

1573-4919

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Hepatitis B virus replication causes oxidative str

Authors: Tamara Severi Chunxiao Ying Joris Robert Vermeesch David Cassiman Lieselotte Cnops Chris Verslype Johan Fevery Lutgarde Arckens Johan Neyts Jos F van Pelt
Publish Date: 2006/09/08
Volume: 290, Issue: 1-2, Pages: 79-85
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Abstract

We used human hepatoma HepAD38 cells in which HBV production is under the control of a tetracyclineregulated promotor to investigate changes induced in the host cell by HBV replication that could contribute to malignant transformation Parameters of oxidative stress malondialdehyde glutathione and cell proliferation were determined at different times after induction 0–96 h In HBVproducing cells the redox status peaked at 72 h cDNA micro array analysis at 72 h post induction revealed 3 groups of genes that were upregulated by HBV i heat shock proteins ii oxidative and metabolic stress and iii growth and apoptosis related genes Continuous HBV production did not accelerate karyotypic changes in cells cultured for 4 months 18 passages In conclusion HBV replication modulates host gene expression and induces oxidative stress In this HepAD38 model early events 0–4 days in the host cell after induction of HBV replication can be studied under strictly defined conditions

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