Authors: Rajagopalan Geetha Baskaran Yogalakshmi S Sreeja K Bhavani Carani Venkatraman Anuradha
Publish Date: 2013/10/31
Volume: 387, Issue: 1-2, Pages: 123-134
Abstract
The reversal effect of troxerutin TX on obesity insulin resistance lipid accumulation oxidative damage and hypertension induced in the highfat–highfructose diet HFFDfed mice model of metabolic syndrome was investigated Adult male Mus musculus mice of body weight 25–30 g were fed either control diet or HFFD Each group was divided into two and treated or untreated with TX 150 mg/kg bw po from the 16th day Assays were done in plasma and heart after 30 and 60 days of the experimental period Significant increase in the levels of glucose and insulin blood pressure BP and oxidative stress were observed after 30 days of HFFD feeding as compared to control Animals fed HFFD for 60 days developed more severe changes in the above parameters compared to those fed for 30 days Hearts of HFFDfed mice registered downregulation of peroxisome proliferatoractivated receptorα and peroxisome proliferatoractivated receptor gamma coactivator1α carnitine palmitoyl transferse1b and AMPactivated protein kinase and upregulation of cluster of differentiation 36 fatty acidbinding protein1 and sterol regulatory elementbinding protein1c after 60 days TX administration restricted obesity as seen by Lee’s index improved whole body insulin sensitivity reduced BP lipid accumulation and oxidative damage upregulated fatty acid FA oxidation and downregulated FA transport and lipogenesis Histology of heart revealed that TX diminishes inflammatory cell infiltration and fatty degeneration in HFFDfed mice The antioxidant property of TX and its ability to influence lipid regulatory genes could be the underlying mechanisms for its beneficial effects
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