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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1007/s10611-006-9035-3

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ISSN

1573-4919

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Tetramerization of SATB1 is essential for regulati

Authors: Minying Zheng Wancai Xing Yabing Liu Meng Li Hao Zhou
Publish Date: 2017/02/15
Volume: 430, Issue: 1-2, Pages: 171-178
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Abstract

Special ATrich sequencebinding protein 1 SATB1 functions as a ‘genome organizer’ in tumorigenesis Our previous report showed that SATB1 forms a tetramer through its Nterminal ubiquitin like domain rather than the proposed PDZ domain In the present study we aim to illustrate whether this oligomerization is critical to its function as a global repressor of gene expression in vivo Luciferase and GST pulldown assays demonstrated that disrupting SATB1’s tetramerization not only affects the activities of promoters but also influences the recruitment of interaction partners Furthermore we developed stable cell lines that overexpressed either the SATB1 tetramer or STAB1 dimer KWN–AAA and monitored global gene expression Gene expression profiling revealed that over 1000 genes were significantly upregulated or downregulated upon the overexpression of SATB1 or the SATB1 KWN–AAA mutant These data implied that SATB1 might regulate gene expression through its different oligomerization state In conclusion we inferred that the oligomerization of SATB1 is pivotal to its function of different biological processesThis study was supported by the State Key Laboratory of Membrane Biology to HZ the State Key Laboratory of Medicinal Chemical Biology to HZ 973 Program Grants 2014CB910201 to JL and National Natural Science Foundation of China Grants 31470755 and 31670758 to JL

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