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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1016/0925-8388(94)91045-6

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ISSN

1573-4919

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Quercitrin a bioflavonoid improves the antioxidant

Authors: Ranganathan Babujanarthanam Purushothaman Kavitha U S Mahadeva Rao Moses Rajasekara Pandian
Publish Date: 2011/06/29
Volume: 358, Issue: 1-2, Pages: 121-
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Abstract

Quercitrin a bio flavonoid was investigated for its antioxidant potential in streptozotocin STZinduced diabetic rats Rats were induced diabetic by a single intraperitoneal injection of streptozotocin 50 mg/kg The levels of fasting plasma glucose and insulin were estimated Lipid peroxidative products and antioxidants were estimated in pancreas liver and kidney Histopathological studies were carried out in these tissues A significant P  005 increase in the levels of fasting plasma glucose and lipid peroxidative products thiobarbituric acid reactive substances and lipid hydroperoxides and a significant P  005 decrease in plasma insulin enzymic antioxidants superoxide dismutase catalase glutathione peroxidase and glutathione reductase and nonenzymic antioxidants reduced glutathione vitamin C and E in diabetic pancreas liver and kidney were observed Oral administration of quercitrin 30 mg/kg for a period of 30 days significantly P  005 decreased fasting plasma glucose increased insulin levels and improved the antioxidant status of diabetic rats by decreasing lipid peroxidative products and increasing enzymic and nonenzymic antioxidants Normal rats treated with quercitrin 30 mg/kg showed no significant P  005 effect on any of the parameters studied Histopathological studies of the pancreas liver and kidney showed the protective role of quercitrin Thus our study clearly shows that quercitrin has antioxidant effect in STZinduced experimental diabetes

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