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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1007/bf02907771

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ISSN

1573-4919

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Glutathione Emphasis Type="Italic"S/Emphasist

Authors: Ana Cristina Ramalhinho José Alberto FonsecaMoutinho Luiza Breitenfeld
Publish Date: 2011/05/11
Volume: 355, Issue: 1-2, Pages: 265-271
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Abstract

Glutathione Stransferases are a superfamily of multifunctional enzymes that play a key role in Phase II metabolism detoxifying therapeutic drugs and various carcinogens by conjugation with glutathione We undertook a case–control study in CentralEastern Portuguese population to evaluate the association of null genotype in GSTM1 and GSTT1 along with the polymorphism in GSTP1 A/G and susceptibility to breast cancer The population sample consisted of 85 patients with histological diagnosis of breast cancer and 102 healthy women Genomic DNA was extracted from blood samples and genotyping analyses were performed by PCRbased methods Odds ratios ORs and 95 confidence intervals 95 CIs were calculated by unconditional logistic regression We found a increased breast cancer risk associated with GSTM1 null genotype OR = 3597 95 CI = 1849–6999 P = 00001 and GSTT1 OR = 2592 95 CI = 1432–4690 P = 0002 but the presence of valine alleles compared to isoleucine alleles in codon 105 in GSTP1 did not increase the risk of breast cancer development The twoway combination of GSTM1 and GTTT1 null genotypes resulted in 8fold increase for breast cancer risk OR = 8287 95 CI = 3124–21980 P = 00001 and the threeway combination of GSTP1 105AA/AG and null genotypes for both GSTM1 and GSTT1 resulted in 5fold increase for breast cancer risk OR = 5040 95 CI = 1392–18248 P = 0016 Our results suggest that GSTM1 and GSTT1 null genotype alone both combined or combined with GSTP1 valine alleles are associated with higher susceptibility to breast cancer development

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