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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1007/s10750-008-9596-5

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ISSN

1573-4919

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Glycine and prolinerich glycoprotein regulates t

Authors: SeiJung Lee KyeTaek Lim
Publish Date: 2009/01/31
Volume: 325, Issue: 1-2, Pages: 187-197
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Abstract

The objective of this study was to investigate the chemopreventive potentials of glycine and prolinerich glycoprotein SNL glycoprotein 150kDa isolated from Solanum nigrum Linne on formation of colonic aberrant crypt foci ACF induced by 12dimethylhydrazine DMH 20 mg/kg in A/J mice Administration of SNL glycoprotein inhibited phosphorylation of extracellular signalregulated kinase ERK expression of colonic proliferating cell nuclear antigen PCNA and frequency of colonic ACF in DMHstimulated mice colon carcinogenesis In addition SNL glycoprotein increased expression of cyclindependent kinase inhibitors p21WAF/Cip1 and p27Kip1 whereas reduced expression of precursor form of apoptosisrelated proteins procaspase3 and propolyADPribosepolymerase PARP in the mice Interestingly the results in this study revealed that SNL glycoprotein has suppressive effects on activity of nuclear factorkappa B NFκB whereas it has stimulatory effect on the expression of p53 accompanying inhibitory effects on expression of NFκBp50 inducible nitric oxide synthase iNOS cyclooxygenase2 COX2 interleukin IL6 and tumor necrosis factor TNFα in DMHstimulated ACF formation Also SNL glycoprotein has inhibitory effects on the formation of thiobarbituric acid reactive substances TBARS on the production of inducible nitric oxide NO and on the release of lactate dehydrogenase LDH in the mice plasma Collectively our findings in this study suggest that SNL glycoprotein has chemopreventive activity via modulation of cell proliferation and apoptosis in DMHtreated A/J mice

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