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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1007/bf03178184

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ISSN

1573-4919

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Suppression of NFκB and IRF1induced transcripti

Authors: Kenji Ogawa Masayuki Funaba Masafumi Tsujimoto
Publish Date: 2007/10/09
Volume: 308, Issue: 1-2, Pages: 9-15
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Abstract

In this study we have characterized the negative regulation of the IL12 p40 expression by TGFβ in macrophages Although murine IL12 p40 promoter contains a putative TGFβ inhibitory element TIE neither mutation nor deletion of the TIE had any effect on the inhibitory activity of TGFβ The NFκB p65 and interferon regulatory factor IRF1 induced promoter activity was suppressed by the expression of a constitutively active TGFβ type I receptor in the presence of Smad3 and Smad4 which was abrogated by expression of an inhibitory Smad Smad7 Transcription of a reporter gene containing three copies of both NFκB and IRF1 elements from the IL12 p40 promoter was significantly repressed by activation of Smaddependent TGFβ pathway In contrast reporter containing three copies of either the NFκB or IRF1 sites was not affected by TGFβSmad pathway These findings indicated that both the NFκB and IRF1 sites are required for the repression of promoter activity of IL12 p40 by TGFβ

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