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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1002/chin.199841049

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ISSN

1573-4919

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Pin1 modulates chemoresistance by upregulating F

Authors: Tao Wang Zi Liu Fan Shi Jiquan Wang
Publish Date: 2016/01/28
Volume: 413, Issue: 1-2, Pages: 179-187
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Abstract

The prolyl isomerase Pin1 which is frequently highly expressed in many different cancers can directly regulate cell proliferation and the cell cycle However the role of Pin1 in chemoresistance remains to be elucidated in cervical cancer The purpose of the present study was to investigate the role of Pin1 in the chemoresistance of cervical cancer The cisplatin resistance was assessed using the MTT assay Pin1 FoxM1 βcatenin Cyclin D1 and cmyc expression levels were detected by RTqPCR or Western blot The results showed that Pin1 expression displayed a similar expression pattern with the resistance to cisplatin in five cervical cell lines Knockdown of Pin1 significantly increased the sensitivity to cisplatin in HeLa cells while Pin1 overexpression decreased the sensitivity to cisplatin in Me180 cells Knockdown of Pin1 significantly downregulated FoxM1 expression in HeLa cells while Pin1 overexpression showed a contrary effect in Me180 cells Besides overexpression of Pin1 markedly increased the protein expression of βcatenin and its target genes cyclin D1 and cmyc FoxM1 siRNA remarkably reversed the promotory effect of pcDNAPin1+ on βcatenin and its target genes cyclin D1 and cmyc in Me180 cells Furthermore we also found that FoxM1 siRNA and IWP2 markedly decreased cell viability and IWP2 decreased cell viability to the maximum extent in the Me180 cells cotransfected with pcDNAPin1+ and FoxM1 siRNA Taken together these data suggest that Pin1 contributes to cisplatin resistance partly by upregulating FoxM1 and Wnt/βcatenin signaling pathway involved in cervical cancer

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