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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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ISSN

1573-4919

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Increased antitumor capability of fibermodified a

Authors: Youguang Zhao Ying Li Qingtang Wang Liang Wang Hang Yang Mingli Li
Publish Date: 2011/03/25
Volume: 353, Issue: 1-2, Pages: 93-
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Abstract

Adenoviral vectors are widely used for cancer therapy and show a tumorsuppressing effect However bladder cancers are found to be resistant against infection of Ad5derived adenoviral vector limiting the application of the existing strategy of gene therapy Therefore efforts to develop novel types of adenoviral vector aimed for improving the viral infection and enhancing expression level of tumorinhibiting transgene is urgently required We constructed a 5/35 fibermodified E1Adeleted adenoviral vector armed with TRAIL gene Its ability to express this gene for inhibition of bladder cancer cell growth was investigated in our work The results showed that this modification in fiber region facilitates adenoviral infection to bladder cancer perhaps due to high expression of CD46 on target cell surface Subsequently we found an enhanced expression level of TRAIL mediated by 5/35 fibermodified adenoviral vectors in bladder cancer cells leading to an increased tumorinhibiting capability of 5/35 adenoviral vector against bladder cancer cells Consistently growth of xenograft tumors in mice was also effectively inhibited by 5/35 fibermodified vectormediated gene therapy strategy The 5/35 fibermodified adenoviral vectorbased gene transfer shows an improved efficacy against bladder cancers The application of this novel gene therapy vector may benefit the patients in clinical bladder cancer treatment

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