Authors: Adriano M de Assis Anderson Rech Aline Longoni Liane N Rotta Cristiane C Denardin Matheus A Pasquali Diogo O Souza Marcos L S Perry José C Moreira
Publish Date: 2011/10/12
Volume: 361, Issue: 1-2, Pages: 151-160
Abstract
Ω3Polyunsaturated fatty acids Ω3PUFAs are known to act as hypolipidaemics but the literature is unclear about the effects that Ω3PUFAs have on oxidative stress in obese and diabetic patients In this study our aim was to investigate the effects of Ω3PUFAs on oxidative stress including antioxidant enzyme activity and hepatic lipid and glycogen metabolism in the livers of diabetic and nondiabetic rats fed on a high fat thermolyzed diet Rats were divided into six groups 1 the control group C 2 the control diabetic group D 3 the high fat thermolyzed diet group HFTD which were fed a diet that was enriched in fat that was heated for 60 min at 180°C 4 the high fat thermolyzed diet diabetic group D + HFTD 5 the high fat thermolyzed diet + Ω3 polyunsaturated fatty acid group HFTD + Ω3 and 6 the high fat thermolyzed diet + Ω3 polyunsaturated fatty acid diabetic group D + HFTD + Ω3 The most important finding of this study was that Ω3PUFAs are able to reduce triglycerides nonesterified fatty acid lipoperoxidation levels advanced glycation end products SOD/CAT enzymatic ratio and CAT immunocontent and increase SOD2 levels in the livers of diabetic rats fed with a HFTD However Ω3PUFAs did not alter the observed levels of protein damage blood glucose or glycogen metabolism in the liver These findings suggest that Ω3PUFAs may represent an important auxiliary adjuvant in combating some diseases like diabetes mellitus insulin resistance and nonalcoholic fatty liver disease
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