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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1016/0165-1765(86)90031-5

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ISSN

1573-4919

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Induction of Fasmediated extrinsic apoptosis p21

Authors: Youn Kyung Choi Hye Sook Seo Han Seok Choi Hyeong Sim Choi Soon Re Kim Yong Cheol Shin SeongGyu Ko
Publish Date: 2011/12/07
Volume: 363, Issue: 1-2, Pages: 119-128
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Abstract

Costunolide C15H20O2 is a sesquiterpene lactone that was isolated from many herbal medicines and it has diverse effects according to previous reports However the anticancer effects and the mechanism of actions are still unknown in breast cancer In this study we first observed that costunolide inhibits cell growth in a doseand timedependent manner To examine the mechanism by which costunolide inhibits cell growth we checked the effect of costunolide on apoptosis and the cell cycle Costunolide induced apoptosis through the extrinsic pathway including the activation of Fas caspase8 caspase3 and degradation of PARP However did not have the same effect on the intrinsic pathway as revealed by analysis of mitochondrial membrane potential Δψm with JC1 dye and expression of Bcl2 and Bax proteins level Furthermore costunolide induced cell cycle arrest in the G2/M phase via decrease in Cdc2 cyclin B1 and increase in p21WAF1 expression independent of p53 pathway in p53mutant MDAMB231 cells and increases Cdc2p21WAF1 binding In addition costunolide had a slight induced effect on ROS generation Among the mechanisms of p21WAF1 induction examined costunolideinduced increase in p21WAF1 expression was related with protein stability and ROS generation Through this study we confirm that costunolide induces G2/M cell cycle arrest and apoptotic cell death via extrinsic pathway in MDAMB231 cells suggesting that it could be a promising anticancer drug especially for ERnegative breast cancer

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