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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1001/archneur.65.4.460

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ISSN

1573-4919

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Betulinic acid inhibits the expression of hypoxia

Authors: Ewa Karna Lukasz Szoka Jerzy A Palka
Publish Date: 2010/02/21
Volume: 340, Issue: 1-2, Pages: 15-20
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Abstract

Although betulinic acid BA is known to induce apoptosis and antiangiogenic response in tumor cells the underlying mechanism of its action is unknown Deregulation of tissue collagen metabolism is one of the consequences of neoplastic transformation The final step of collagen degradation is mediated by prolidase EC34139 which may play a role in angiogenesis The formation of new blood vessels is regulated by the hypoxiainducible factor 1 HIF1 The expression of HIF1 correlates with hypoxiainduced angiogenesis as a result of the induction of vascular endothelial cell growth factor VEGF Since BA evokes anticancer activity its effect on collagen biosynthesis HIF1α and VEGF expressions as well as prolidase activity and expression was studied in cultured endometrial adenocarcinoma EA cells It was found that BA inhibits collagen biosynthesis in EA cells 53H proline incorporation assay It was accompanied by a parallel decrease in prolidase activity and expression and decrease in expressions of α1 and α2 integrins HIF1α and VEGF western immunoblot analysis in cultured human EA cells The data suggest that BA may have antiangiogenic potential by inhibition of prolidase HIF1α and VEGF expressions and inhibition of collagen biosynthesis

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