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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1007/s00158-007-0169-4

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ISSN

1573-4919

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Nanoceria protects from alterations in oxidative m

Authors: David GonzálezFlores Milena De Nicola Emanuele Bruni Fanny Caputo Ana B Rodríguez José A Pariente Lina Ghibelli
Publish Date: 2014/08/23
Volume: 397, Issue: 1-2, Pages: 245-253
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Abstract

The present study is aimed to determine the protective effect of a novel nanoparticle with antioxidant properties nanoceria on reactive oxygen species ROS production and calcium signaling evoked by the tumor necrosis factoralpha TNFα in combination with cycloheximide CHX on apoptosis in the human histiocytic lymphoma cell line U937 Our results show that treatment of U937 cells with 10 ng/mL TNFα in combination with 1 μg/mL CHX led to several Ca2+ alterations These stimulatory effects on calcium signals were followed by intracellular ROS production and mitochondria membrane depolarization as well as a timedependent increase in caspase8 and 9 activities Our results show that the pretreatment with well known antioxidants such as trolox and Nacetyl cysteine NAC partially reduced the apoptotic effects due to the administration of TNFα plus cycloheximide Furthermore nanoceria had a stronger protective effect than trolox or NAC Our findings also suggest that TNFα plus cycloheximideinduced apoptosis is dependent on alterations in cytosolic concentration of calcium Ca2+c and ROS generation in human histiocytic U937 cellsThis work was supported by MICINNFEDER BFU 201015049 and 2008 PRIN Project “miRNA in diagnosis and experimental therapy via nanovectors of pleural malignant mesothelioma” of the Italian Ministry of Education University and Research MIUR Thanks to Prof Enrico Traversa Dipartamento di Scienze e Tecnologie Chimiche Università si Roma TorVergata for providing nanoceria and scientific support

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