Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Mol Cell Biochem

Search In Journal Title:

Abbravation: Molecular and Cellular Biochemistry

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1001/archoto.2009.42-a

Search In DOI:

ISSN

1573-4919

Search In ISSN:
Search In Title Of Papers:

Antimetastatic potential of fisetin involves inact

Authors: ChiSheng Chien KunHung Shen JauShyang Huang ShianChin Ko YuanWei Shih
Publish Date: 2009/07/26
Volume: 333, Issue: 1-2, Pages: 169-
PDF Link

Abstract

Fisetin 33′4′7tetrahydroxyflavone a naturally occurring flavonoid has been reported to possess some anticancer and antiinflammation capabilities In this study fisetin has exhibited inhibitory effects on the adhesion migration and invasion ability of a highly metastatic PC3 cells under noncytotoxic concentrations Gelatin zymography assay showed that fisetin inhibited the matrix metalloproteinase2 MMP2 and matrix metalloproteinase9 MMP9 activities Our result also showed that fisetin could inhibit the phosphorylation of cJun Nterminal kinase 1 and 2 JNK1/2 and Akt Moreover fisetin significantly decreased the nuclear levels of nuclear factor kappa B NFκB cFos and cJun and the binding abilities of NFκB and activator protein1 AP1 Also the results showed that the protein and mRNA levels of MMP2 and MMP9 were significantly reduced by Western blot and semiquantitative RTPCR Further treating specific inhibitors for PI3K Wortmannin or JNK SP600125 to PC3 cells could reduce the protein expressions of MMP2 and MMP9 These results showed fisetin could inhibit the metastatic ability of PC3 by reducing MMP2 and MMP9 expressions through suppressing phosphoinositide 3kinase/Akt PI3K/Akt and JNK signaling pathways This suggested fisetin can serve as a potential candidate for treating cancer metastasis

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells
  2. 4-(4-Chloro-2-methylphenoxy)- N -hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells
  3. Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental rat model
  4. Retinol-binding protein 4 as a risk factor for cholesterol gallstone formation
  5. FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction
  6. Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer
  7. Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts
  8. The synergistic induction of cyclooxygenase-2 in lung fibroblasts by angiotensin II and pro-inflammatory cytokines
  9. Fatty acylation enhances cellular localization of dansylated phenylalanines
  10. Tetramerization of SATB1 is essential for regulating of gene expression
  11. Retraction Note to: Adipose stromal-vascular fraction-derived paracrine factors regulate adipogenesis
  12. The molecular interaction of a copper chelate with human P-glycoprotein
  13. Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation
  14. Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on γ-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death
  15. Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3β and osteopontin
  16. Increased antitumor capability of fiber-modified adenoviral vector armed with TRAIL against bladder cancers
  17. Hormonal imbalance and disturbances in carbohydrate metabolism associated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats
  18. Silencing SATB1 inhibits proliferation of human osteosarcoma U2OS cells
  19. Epigenetics in anoxia tolerance: a role for histone deacetylases
  20. Characterization of a multidrug-resistant chronic myeloid leukemia cell line presenting multiple resistance mechanisms
  21. Increased synthesis of folate transporters regulates folate transport in conditions of ethanol exposure and folate deficiency
  22. Apollon/Bruce is upregulated by Humanin
  23. Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration
  24. Pin1 modulates chemo-resistance by up-regulating FoxM1 and the involvements of Wnt/β-catenin signaling pathway in cervical cancer
  25. Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators
  26. Glutathione S -transferase M1, T1, and P1 genotypes and breast cancer risk: a study in a Portuguese population
  27. Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues
  28. Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231
  29. Ω3-Polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes, and reduce lipid content but do not alter glycogen metabolism in the livers of diabetic rats fed on a high fat thermolyzed diet
  30. Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23
  31. Role of SIRT1 in Streptococcus pneumoniae -induced human β-defensin-2 and interleukin-8 expression in A549 cell
  32. Betulinic acid inhibits the expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in human endometrial adenocarcinoma cells
  33. Macrophage migration inhibitory factor does not modulate co-activation of androgen receptor by Jab1/CSN5
  34. Growth and sex effects on the expression of syndecan-4 and glypican-1 in turkey myogenic satellite cell populations
  35. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid α-glucosidase in Caenorhabditis elegans
  36. Suppression of NF-κB and IRF-1-induced transcription of the murine IL-12 p40 by transforming growth factor-β Smad pathway in macrophages
  37. Exon array analysis reveals genetic heterogeneity in atypical femoral fractures. A pilot study
  38. Manganese supplementation increases adiponectin and lowers ICAM-1 and creatinine blood levels in Zucker type 2 diabetic rats, and downregulates ICAM-1 by upregulating adiponectin multimerization protein (DsbA-L) in endothelial cells
  39. Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice
  40. Antagonizing canonical Wnt signaling pathway by recombinant human sFRP4 purified from E. coli and its implications in cancer therapy
  41. Glycine- and proline-rich glycoprotein regulates the balance between cell proliferation and apoptosis for ACF formation in 1,2-dimethylhydrazine-treated A/J mice
  42. Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells
  43. Nanoceria protects from alterations in oxidative metabolism and calcium overloads induced by TNFα and cycloheximide in U937 cells: pharmacological potential of nanoparticles
  44. Ghrelin and obestatin expression in oral squamous cell carcinoma: an immunohistochemical and biochemical study
  45. CNTF-ACM promotes mitochondrial respiration and oxidative stress in cortical neurons through upregulating L-type calcium channel activity
  46. Low ethanol intake prevents salt-induced hypertension in WKY rats
  47. miR-202 suppresses proliferation and induces apoptosis of osteosarcoma cells by downregulating Gli2
  48. Screening of chemopreventive effect of naringenin-loaded nanoparticles in DMBA-induced hamster buccal pouch carcinogenesis by FT-IR spectroscopy
  49. Effects of tamoxifen on myocardial ischemia-reperfusion injury model in ovariectomized rats
  50. Muscle regeneration occurs to coincide with mitochondrial biogenesis
  51. Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking
  52. Troxerutin suppresses lipid abnormalities in the heart of high-fat–high-fructose diet-fed mice
  53. Erratum to: A comparative study of glycoproteomes in androgen-sensitive and -independent prostate cancer cell lines
  54. Diazoxide-induced respiratory inhibition – a putative mitochondrial K ATP channel independent mechanism of pharmacological preconditioning
  55. Upregulation of Glyoxalase I fails to Normalize Methylglyoxal Levels: A Possible Mechanism for Biochemical Changes in Diabetic Mouse Lenses
  56. The dependence of enhanced lysosomal activity on the cellular aging of bovine aortic endothelial cells
  57. Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin
  58. Oxidant/antioxidant effects of chronic exposure to predator odor in prefrontal cortex, amygdala, and hypothalamus
  59. Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways
  60. Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis
  61. Insulin ameliorates miR-1-induced injury in H9c2 cells under oxidative stress via Akt activation
  62. The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor
  63. Enteroaggregative Escherichia coli infection induces IL-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-κB and AP-1 in INT-407 cells
  64. Lupeol and its ester inhibit alteration of myocardial permeability in cyclophosphamide administered rats
  65. RC3/neurogranin negatively regulates extracellular signal-regulated kinase pathway through its interaction with Ras
  66. Oxidant/anti-oxidant dynamics in patients with advanced cervical cancer: correlation with treatment response
  67. Quaternary structural parameters of the congenital cataract causing mutants of αA-crystallin
  68. Interleukin-6 as possible early marker of stress response after femoral fracture
  69. Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats
  70. C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes
  71. AP4 activates cell migration and EMT mediated by p53 in MDA-MB-231 breast carcinoma cells
Search Result: